Πέμπτη, 31 Αυγούστου 2017

Depression increases risk for sudden cardiac death in stable CAD | ESC

Depression increases risk for sudden cardiac death in stable CAD | ESC

  • RSi Communications
Risk is independent of other clinical risk factors and left ventricular function.
Takeaway
  • Coronary disease patients with depressive symptoms have increased risk of sudden cardiac death (SCD) independent of other clinical risk factors and left ventricular function. 
Why this matters
  • Results emphasize the importance of screening for depression in patients with CAD. 
Study design
  • Researchers at the University of Oulu, Finland, assessed the association of depressive symptoms and the risk of sudden cardiac death.
  • Patients with angiographically documented CAD (n=1928, mean age 67 y) underwent clinical examination, including screening for depression by Depression Scale (0-30), extensive risk profiling including echocardiography at baseline.
  • Patients were divided into quartiles based on score obtained by Depression Scale (<2, 2-4, 5-7, ≥8).  
Key results
  • Over a median follow-up period of 6.4 y, the incidence of SCD was 1.1% (n=450, 5 events), 2.0% (n=459, 9 events), 2.4% (n=542, 13 events), and 4.4% (n=477, 21 events) from the lowest to the highest quartile of the Depression Scale score.
  • The patients in the highest quartile of Depression Scale score had 3.9­ (P=.006), 2.3­ (P=.035), and 1.9 ­fold risk for SCD compared to patients in the lowest, 2nd, and 3rd quartile, respectively.
  • Depression Scale score was not associated with non­sudden cardiac death.

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