MEDICAL NEWS
Role of
neutrophil extracellular traps in coronary thrombosis in COVID-19
patients
Heather Mason | 06 January 2021
View more articles on:
Acute Coronary Syndromes (ACS)
A study in COVID-19 patients who underwent primary coronary interventions for ST-elevated myocardial infarction (STEMI) revealed that the intense formation of neutrophil extracellular traps (NETs) lead to the occlusion of microvessels, thus playing a major role in STEMI pathogenesis, according to an article published in JAMA Cardiology.
The analysis included five patients with COVID-19 who experienced a STEMI, comparing them with a series of 50 patients who suffered STEMI prior to COVID-19 emergence. The researchers collected coronary thrombus samples during primary coronary intervention to determine if the excessive formation of NETs was implied in coronary thrombosis.
The findings show that all patients with COVID-19 had abundant NETs in their thrombi, with a significantly higher burden than in the comparison series. All thrombi from patients with COVID-19 were composed of fibrin and polymorphonuclear cells. None of them showed fragments of atherosclerotic plaque or iron deposits indicative of previous episodes of plaque rupture, unlike most coronary thrombi from patients with STEMI without infection.
Despite the small sample size, the authors say the results reinforce the relevant role of NETs in the pathogenesis of SARS-CoV-2 infection, supporting the idea that targeting intravascular NETs might prevent coronary thrombosis in patients with severe COVID-19.
Blasco A, Coronado M-J, Hernández-Terciado F, Martín P, Royuela A, Ramil E, et al. Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction. JAMA Cardiol 2020. https://doi.org/10.1001/jamacardio.2020.7308.
0 σχόλια:
Δημοσίευση σχολίου